In the context of Gastrointestinal Stromal Tumors (GIST), which of the following is the most common driver mutation?
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Correct answer: c-KIT receptor tyrosine kinase
GISTs arise from the interstitial cells of Cajal. Approximately 75-85% of these tumors harbor a gain-of-function mutation in the c-KIT proto-oncogene, which serves as a target for imatinib therapy.
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