Gastrointestinal Pathology · Pathology

Which complication is specifically associated with chronic atrophic gastritis due to autoimmune etiology?

  1. Iron deficiency microcytic anemia
  2. Pernicious anemia and Vitamin B12 deficiency
  3. Massive hemorrhagic shock from acute gastric bleeding
  4. Reactive secondary amyloidosis of the gastric mucosa
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Correct answer: Pernicious anemia and Vitamin B12 deficiency

Autoimmune gastritis involves antibodies against parietal cells and intrinsic factor. This leads to oxyntic mucosal atrophy and failure of B12 absorption, resulting in megaloblastic (pernicious) anemia.

Difficulty: Medium Question 15 of 20

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