Cell Death: Necrosis · Pathology

What is the biochemical hallmark that distinguishes necrosis from apoptosis?

  1. Activation of the electron transport chain
  2. Loss of plasma membrane integrity
  3. Requirement of ATP for cell destruction
  4. Cleavage of DNA into 180-200 base pair fragments
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Correct answer: Loss of plasma membrane integrity

The loss of plasma membrane integrity is a fundamental feature of necrosis, leading to the leakage of cellular contents and subsequent inflammation. In contrast, apoptosis maintains an intact plasma membrane to prevent an inflammatory response.

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