During necrosis, the increased eosinophilia seen in the cytoplasm on H&E staining is primarily due to:
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Correct answer: Binding of eosin to denatured cytoplasmic proteins
Necrotic cells show increased eosinophilia (pinkness) because denatured cytoplasmic proteins bind more readily to the acidic dye eosin. Additionally, there is a loss of cytoplasmic RNA, which normally provides a basophilic (blue) tint.
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