Cell Death: Necrosis · Pathology

In the context of cell death, what is 'pyknosis'?

  1. Fragmentation of the nucleus
  2. Nuclear shrinkage and increased basophilia
  3. Rupture of the nuclear envelope
  4. Fading of the chromatin due to DNAse activity
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Correct answer: Nuclear shrinkage and increased basophilia

Pyknosis is characterized by nuclear shrinkage and increased basophilia. In this process, the DNA condenses into a solid, shrunken dark mass, representing an early stage of nuclear changes in necrotic cells.

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