Thyroid Disorders · Pathology

What is the characteristic histological finding in Papillary Thyroid Carcinoma?

  1. Sheets of parafollicular C cells
  2. Psammoma bodies and 'Orphan Annie eye' nuclei
  3. Invasion of the tumor capsule by follicular cells
  4. Extensive Riedel's fibrous tissue
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Correct answer: Psammoma bodies and 'Orphan Annie eye' nuclei

Papillary carcinoma is identified by unique nuclear features including clear or empty-appearing nuclei (Orphan Annie eye) and nuclear grooves. Psammoma bodies, which are laminated calcified structures, are also frequently present in the papillae.

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