A patient is found to have a thyroid mass and an elevated serum calcitonin level. Biopsy shows an amyloid-rich stroma. What is the most likely diagnosis?
Show answer and explanation
Correct answer: Medullary carcinoma
In medullary thyroid carcinoma, the neoplastic C cells secrete procalcitonin, which can deposit in the tumor stroma as amyloid. This amyloid stains positive with Congo red and shows apple-green birefringence under polarized light.
Keep practicing
More Thyroid Disorders questions
- Which genetic mutation is most commonly associated with Medullary Thyroid Carcinoma?
- Riedel thyroiditis is characterized by which of the following?
- In Graves disease, the 'scalloped' appearance of the colloid at the edge of the follicular epithelial cells represents:
- A 75-year-old patient with a long-standing multinodular goiter presents with a rapidly enlarging, painful neck mass and dyspnea. Histology…
- Which of the following describes the pathogenesis of the ophthalmopathy seen in Graves disease?
- What is the most common cause of endemic goiter worldwide?