A 35-year-old woman presents with heat intolerance, weight loss, and exophthalmos. Which of the following is the most likely underlying mechanism?
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Correct answer: Autoantibodies against the TSH receptor (TSI)
Graves disease is caused by thyroid-stimulating immunoglobulins (TSI) that bind to and activate the TSH receptor, mimicking the action of TSH. This leads to autonomous hyperthyroidism and characteristic clinical features like ophthalmopathy.
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