Thyroid Disorders · Pathology

What is the most common cause of endemic goiter worldwide?

  1. Autoimmunity
  2. Iodine deficiency
  3. Lithium therapy
  4. Congenital dyshormonogenesis
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Correct answer: Iodine deficiency

Dietary iodine deficiency is the most common cause of goiter globally. Lack of iodine leads to decreased thyroid hormone synthesis, a compensatory rise in TSH, and subsequent hypertrophy and hyperplasia of the follicular cells.

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