In Graves disease, the 'scalloped' appearance of the colloid at the edge of the follicular epithelial cells represents:
Show answer and explanation
Correct answer: Increased endocytosis of colloid by hyperactive cells
The scalloping (clear vacuoles at the periphery of the colloid) indicates rapid resorption and processing of thyroglobulin by the columnar-shaped, hyperactive follicular cells stimulated by TSI.
Keep practicing
More Thyroid Disorders questions
- A 75-year-old patient with a long-standing multinodular goiter presents with a rapidly enlarging, painful neck mass and dyspnea. Histology…
- Which of the following describes the pathogenesis of the ophthalmopathy seen in Graves disease?
- What is the most common cause of endemic goiter worldwide?
- Thyroid lymphoma is most likely to develop in the background of which pre-existing condition?
- Which of the following lab profiles is most consistent with primary hypothyroidism?
- A 'cold' nodule on a radioactive iodine uptake scan is most concerning for: