Why does burn injury sometimes lead to multiple-organ dysfunction syndrome (MODS) even when initial fluid resuscitation is adequate?
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Correct answer: Because systemic inflammation, endothelial injury, and hypoperfusion persist
Burn injury triggers systemic inflammatory responses, endothelial dysfunction, and ongoing tissue damage that can progress to MODS despite adequate initial resuscitation.
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More Pathophysiology of Burn Injury questions
- What is the primary reason for intravascular hypovolemia in the immediate period after a major thermal burn injury (>30% TBSA)?
- Which cellular mechanism contributes to cellular swelling and edema formation after a burn injury?
- What type of shock is characteristic of burn injury in the early phase?
- Which of the following is a hallmark hemodynamic change during the early post-burn period?
- What role do inflammatory mediators and oxidative stress play in burn pathophysiology?
- Why does hypoalbuminemia occur early in major burn injuries?