Why is nerve regeneration significantly more successful in the Peripheral Nervous System (PNS) than in the Central Nervous System (CNS)?
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Correct answer: Schwann cells promote regrowth, while CNS glia inhibit it
Schwann cells produce a growth-promoting environment via neurotrophins and basement membranes. In contrast, CNS myelin produced by oligodendrocytes contains inhibitory proteins (like Nogo), and astrocytes form a physical glial scar.
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More Nerve Regeneration questions
- What is the clinical consequence if a regenerating axon fails to find its original endoneurial tube and forms a disorganized mass?
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- In the CNS, the formation of a 'glial scar' is primarily attributed to which cell type?
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