The autoimmune disease Pemphigus vulgaris involves the production of antibodies against which junctional component?
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Correct answer: Desmoglein
Pemphigus vulgaris targets desmogleins, which are the cadherin family proteins that form the 'glue' in desmosomes. The destruction of these junctions leads to acantholysis (loss of cell-to-cell adhesion) and severe blistering of the skin and mucous membranes.
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