Microscopy Resolution · Histology

Which of the following changes would most effectively improve the resolution of a light microscope?

  1. Using a light source with a longer wavelength
  2. Decreasing the numerical aperture of the objective lens
  3. Using blue light for illumination instead of red light
  4. Increasing the thickness of the tissue section
Show answer and explanation

Correct answer: Using blue light for illumination instead of red light

Blue light has a shorter wavelength than red light. According to the Abbe equation, decreasing the wavelength decreases the minimum resolvable distance, thereby improving resolution.

Difficulty: Medium Question 3 of 20

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