Which of the following describes 'crush artifact' commonly seen in small biopsies?
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Correct answer: Nuclear smearing and distortion from pressure
Crush artifact occurs when excessive force is applied with forceps or during the biopsy procedure. It causes the nuclei to appear elongated and 'smeary,' making it difficult to distinguish between small cell carcinoma and normal lymphocytes.
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More Histological Artifacts questions
- What is the likely cause of 'parched earth' or 'cracked' appearance in the tissue when viewed under the microscope?
- Which artifact is characterized by empty circular spaces within the cytoplasm of cells, often seen in frozen sections?
- The presence of a dark, opaque, granular precipitate throughout a section fixed in Zenker's or B-5 fixative is likely:
- If a tissue section appears 'cloudy' or 'milky' after clearing with xylene and before mounting, what is the most likely cause?
- What histological artifact is caused by the slow rate of fixative penetration, leading to enzymatic degradation of the tissue center?
- Which artifact results in a 'shish-kebab' or 'telescoping' effect where tissue layers are pushed into one another?