The 3' to 5' exonuclease activity of DNA Polymerase III is primarily used for:
Show answer and explanation
Correct answer: Proofreading and correcting mismatched bases
The 3' to 5' exonuclease activity of DNA Polymerase III allows it to detect and excise a mismatched nucleotide immediately after it is added, then resume correct synthesis — an essential proofreading mechanism that maintains replication fidelity.
Practice all 20 DNA Replication: Mechanisms and Enzymes questions
Keep practicing
More DNA Replication: Mechanisms and Enzymes questions
- Which specific region of the DNA serves as the starting point for replication?
- Eukaryotic DNA replication faces the 'end-replication problem' at the telomeres. Which enzyme solves this by extending the ends of chromoso…
- What is the role of the 'Sliding Clamp' (beta-subunit in E. coli) in DNA replication?
- During replication, which of the following provides the energy required for the formation of the phosphodiester bond?
- Which eukaryotic DNA polymerase is primarily responsible for the synthesis of the lagging strand?
- The direction of DNA synthesis is always: