Which of the following triggers would most likely activate the intrinsic apoptotic pathway?
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Correct answer: Severe DNA damage caused by UV radiation
Internal stressors like DNA damage, oxidative stress, or nutrient deprivation trigger the intrinsic pathway. Fas ligand binding is the classic trigger for the extrinsic pathway.
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More Apoptosis and Its Significance questions
- The cleavage of which structural protein by caspases leads to the characteristic 'blebbing' of the plasma membrane?
- What is the biological significance of apoptosis in the context of viral infections?
- Which of the following describes the morphological hallmark of apoptosis that distinguishes it from necrosis?
- The 'intrinsic pathway' of apoptosis is primarily regulated by which organelle?
- Which family of proteins acts as the primary 'molecular switch' to either promote or inhibit apoptosis?
- During the execution phase of apoptosis, which enzymes are responsible for the deliberate proteolysis of cellular components?