Muscle Physiology: Contraction Mechanisms · Zoology

What is the primary cause of 'Rigor Mortis' after death?

  1. Excessive release of acetylcholine at the neuromuscular junction
  2. Absence of ATP, which is required for myosin heads to detach from actin
  3. Rapid breakdown of troponin by lysosomal enzymes after death
  4. Build-up of lactic acid causing muscle membrane depolarization
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Correct answer: Absence of ATP, which is required for myosin heads to detach from actin

ATP binding is necessary to break the cross-bridge between myosin and actin. When ATP production ceases after death, the myosin heads remain 'locked' to the actin, causing permanent muscle stiffness until tissue decay begins.

Difficulty: Medium Question 6 of 20

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