Respiratory Mechanics and Gas Exchange · USMLE Step 1

Which of the following would decrease lung compliance under pathological conditions?

  1. Increased surfactant production
  2. Loss of alveolar elastic tissue, as in emphysema
  3. Thickening of alveolar walls (fibrosis)
  4. Increased airway diameter
Show answer and explanation

Correct answer: Thickening of alveolar walls (fibrosis)

Thickening of alveolar walls (as in pulmonary fibrosis) increases stiffness and reduces compliance, making lung expansion more difficult.

Difficulty: Medium Question 5 of 20

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