Respiratory Mechanics and Gas Exchange · USMLE Step 1

Which of the following factors does NOT significantly affect the diffusion of O₂ and CO₂ across the alveolar–capillary membrane?

  1. Alveolar surface area
  2. Thickness of the respiratory membrane
  3. Ventilation–perfusion matching
  4. Blood flow in systemic arteries
Show answer and explanation

Correct answer: Blood flow in systemic arteries

Gas diffusion depends on alveolar surface area, membrane thickness, and efficient V/Q matching; systemic arterial blood flow doesn’t directly affect diffusion across the alveolar capillaries.

Difficulty: Medium Question 8 of 20

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