Respiratory Mechanics and Gas Exchange · USMLE Step 1

What is ‘physiologic dead space’ in the context of ventilation and gas exchange?

  1. Air that reaches alveoli and participates in gas exchange
  2. Air in conducting airways plus non-perfused alveoli
  3. The tidal volume during maximal expiration
  4. Air trapped in the alveoli at residual volume
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Correct answer: Air in conducting airways plus non-perfused alveoli

Physiologic dead space includes anatomical dead space (conducting airways) plus any alveoli that are ventilated but not perfused; this air does not participate in gas exchange.

Difficulty: Medium Question 6 of 20

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