Respiratory Mechanics and Gas Exchange · USMLE Step 1

Which of the following best describes the effect of increasing physiologic dead space on alveolar ventilation (V_A), assuming constant minute ventilation?

  1. Alveolar ventilation increases
  2. Alveolar ventilation decreases
  3. Alveolar ventilation remains unchanged
  4. Minute ventilation becomes zero
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Correct answer: Alveolar ventilation decreases

If physiologic dead space increases, more of the tidal volume fails to reach perfused alveoli, so alveolar ventilation decreases even if minute ventilation is unchanged.

Difficulty: Medium Question 17 of 20

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