Neurophysiology and Synapses · USMLE Step 1

Which presynaptic structure is specialized for the precise release of neurotransmitter vesicles upon arrival of an action potential?

  1. Axon hillock
  2. Nodes of Ranvier
  3. Presynaptic active zone
  4. Dendritic spine
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Correct answer: Presynaptic active zone

The active zone is the region in the presynaptic terminal enriched with cytomatrix proteins that tether synaptic vesicles and mediate their rapid fusion and neurotransmitter release upon calcium influx.

Difficulty: Medium Question 10 of 28

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