Neurophysiology and Synapses · USMLE Step 1

What is the approximate typical synaptic delay at a chemical synapse between presynaptic action potential arrival and postsynaptic response?

  1. 0.01–0.05 ms
  2. 0.5–1.0 ms
  3. 5–10 ms
  4. 50–100 ms
Show answer and explanation

Correct answer: 0.5–1.0 ms

At chemical synapses, the synaptic delay is typically around 0.5–1.0 milliseconds, reflecting time needed for neurotransmitter release, diffusion across the cleft, and receptor binding.

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