Neurophysiology and Synapses · USMLE Step 1

Which of the following neurotransmitters is most likely to produce an inhibitory postsynaptic potential (IPSP) in the central nervous system?

  1. Glutamate
  2. Acetylcholine
  3. GABA
  4. Norepinephrine
Show answer and explanation

Correct answer: GABA

GABA is a major inhibitory neurotransmitter in the adult CNS; its binding typically opens Cl⁻ channels (or K⁺ channels), causing hyperpolarization and an inhibitory postsynaptic potential.

Difficulty: Medium Question 7 of 28

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