Muscle Physiology and Contraction · USMLE Step 1

Which structure in the muscle fiber ensures rapid propagation of action potentials into the interior of the fiber to trigger Ca²⁺ release from the SR?

  1. Sarcoplasmic reticulum
  2. Transverse tubules
  3. Mitochondria
  4. Endomysium
Show answer and explanation

Correct answer: Transverse tubules

T-tubules are invaginations of the sarcolemma that carry the action potential deep into the muscle fiber, coupling membrane excitation to Ca²⁺ release from the sarcoplasmic reticulum.

Difficulty: Medium Question 12 of 20

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