Muscle Physiology and Contraction · USMLE Step 1

Which of the following best describes “summation” of contractions in skeletal muscle physiology?

  1. More Ca²⁺ is released with each action potential
  2. Recruitment of additional motor units only
  3. Successive stimuli prevent full relaxation, boosting tension
  4. Switching from slow-twitch to fast-twitch fibers
Show answer and explanation

Correct answer: Successive stimuli prevent full relaxation, boosting tension

When stimuli arrive in rapid succession before the muscle fully relaxes, cytosolic Ca²⁺ stays elevated and successive contractions build on one another, so summation increases the overall tension.

Difficulty: Medium Question 18 of 20

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