Which of the following endocrine regulation scenarios illustrates a ‘short-loop’ negative feedback mechanism?
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Correct answer: Pituitary hormone inhibiting hypothalamic releasing hormone secretion
Short-loop negative feedback refers to a pituitary hormone acting back on the hypothalamus to inhibit secretion of its releasing hormone — matching 'pituitary hormone inhibiting hypothalamic releasing hormone secretion.' Thyroid hormone or cortisol inhibiting the hypothalamus/pituitary are long-loop feedback, and insulin inhibiting glucagon is local paracrine regulation within the pancreas, not a short-loop axis mechanism.
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