Endocrine regulation · USMLE Step 1

Which of the following describes an endocrine control mechanism where a hormone from a target gland rapidly suppresses its upstream regulators (within minutes)?

  1. Slow (genomic) negative feedback
  2. Fast (non-genomic) negative feedback
  3. Positive feedback
  4. Long-loop positive feedback
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Correct answer: Fast (non-genomic) negative feedback

Fast (non-genomic) negative feedback — such as rapid feedback inhibition of the HPA axis by cortisol — can suppress upstream hormone release within minutes, independent of gene transcription.

Difficulty: Medium Question 20 of 23

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