Endocrine regulation · USMLE Step 1

Which of the following correctly describes the control of (TSH) secretion under normal physiology?

  1. TSH release is stimulated by high circulating T3/T4
  2. TSH release is independent of hypothalamic input
  3. TSH release increases when circulating T3/T4 levels fall
  4. TSH release occurs only in response to neural stimuli
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Correct answer: TSH release increases when circulating T3/T4 levels fall

When circulating thyroid hormone (T3/T4) levels fall, reduced negative feedback prompts increased TRH and TSH secretion to stimulate the thyroid gland.

Difficulty: Medium Question 13 of 23

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