Cardiac Cycle and Hemodynamics · USMLE Step 1

During which phase of the cardiac cycle does isovolumetric contraction occur?

  1. After atrial systole, before semilunar valves open
  2. During rapid ejection of blood into the aorta
  3. During isovolumetric relaxation of the ventricle
  4. During passive ventricular filling phase
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Correct answer: After atrial systole, before semilunar valves open

Isovolumetric contraction begins right after atrioventricular valve closure (after atrial systole) and before the semilunar valves open. The ventricles contract, pressure rises, but volume remains constant because all valves are closed.

Difficulty: Medium Question 2 of 21

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