Endocrine pharmacotherapy · USMLE Step 1

A patient with Cushing syndrome undergoes medical therapy before surgery. Which drug inhibits 11β-hydroxylase?

  1. Metyrapone
  2. Octreotide
  3. Ketoconazole
  4. Fludrocortisone
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Correct answer: Metyrapone

Metyrapone blocks cortisol synthesis by inhibiting 11β-hydroxylase, used diagnostically and therapeutically.

Difficulty: Medium Question 6 of 20

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