Antimicrobials and Resistance · USMLE Step 1

A patient taking tetracycline is advised not to take it with milk. Which mechanism explains this interaction?

  1. Enhanced hepatic drug metabolism
  2. Insoluble calcium chelate formation
  3. Increased renal drug clearance
  4. Decreased hepatic drug uptake
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Correct answer: Insoluble calcium chelate formation

Dairy products chelate tetracyclines, reducing absorption and antibiotic effectiveness.

Difficulty: Medium Question 4 of 20

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