Antimicrobials and Resistance · USMLE Step 1

A patient on linezolid develops bone marrow suppression. What is this drug’s mechanism?

  1. Binds 50S and prevents translocation
  2. Blocks 70S initiation complex formation
  3. Inhibits bacterial DNA gyrase
  4. Inhibits dihydrofolate reductase
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Correct answer: Blocks 70S initiation complex formation

Linezolid prevents formation of the 70S initiation complex, inhibiting protein synthesis.

Difficulty: Medium Question 8 of 20

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