Neoplasia and Cancer Biology · USMLE Step 1

Which phenomenon describes neoplastic cells acquiring the ability to divide indefinitely, avoiding normal replicative senescence?

  1. Angiogenesis
  2. Replicative immortality
  3. Differentiation
  4. Cell-cell adhesion
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Correct answer: Replicative immortality

Replicative immortality is a hallmark of cancer allowing cells to bypass senescence and divide indefinitely, often via maintenance of telomere length or activation of telomerase.

Difficulty: Medium Question 12 of 20

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