Which factor is most critical in determining whether injured tissue regenerates completely or scars by fibrosis during repair?
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Correct answer: Intact stem cells and basement membrane
Tissue regeneration requires viable parenchymal/regenerative cells and an intact basement membrane/ECM framework; if these are lost, repair proceeds via scar formation/fibrosis.
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More Inflammation and repair questions
- During which phase of wound healing does neovascularization (angiogenesis) primarily occur?
- Which of the following is one of the cardinal signs of acute inflammation?
- During the vascular phase of acute inflammation, which change occurs first?
- Which cell type is the predominant leukocyte in the first 24 hours of acute inflammation?
- What is the main function of macrophages during the wound-healing process after acute inflammation?
- Which of the following describes the correct sequence of wound healing phases under normal circumstances?