Genetic and Pediatric Diseases · USMLE Step 1

Which organ systems are most characteristically affected in cystic fibrosis, leading to chronic clinical problems?

  1. Brain and spinal cord (central nervous system)
  2. Lungs and pancreas (respiratory and digestive systems)
  3. Bones and joints (musculoskeletal system)
  4. Liver and spleen (hepatic and lymphoid)
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Correct answer: Lungs and pancreas (respiratory and digestive systems)

CF causes thick mucus secretions that obstruct airways leading to recurrent lung infections, and also impair pancreatic exocrine function causing malabsorption and digestive problems.

Difficulty: Medium Question 4 of 20

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