Which of the following genetic diseases arises from genomic imprinting or uniparental disomy rather than simple gene mutation or chromosome number change?
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Correct answer: Prader–Willi syndrome
Prader–Willi syndrome results from absence of active paternal genes on chromosome 15 (due to paternal deletion or maternal uniparental disomy), an imprinting disorder — unlike typical single-gene or chromosomal disorders.
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