Multisystem: Shock, Sepsis and Metabolic Syndromes · USMLE Step 1

A patient with septic shock develops lactic acidosis. Which mechanism contributes most directly?

  1. Hyperglycemic osmotic diuresis
  2. Decreased tissue oxygen delivery
  3. Overproduction of ketone bodies
  4. Excessive insulin release
Show answer and explanation

Correct answer: Decreased tissue oxygen delivery

Tissue hypoperfusion in shock leads to anaerobic metabolism and lactate accumulation. Lactic acidosis is a marker of poor perfusion.

Difficulty: Medium Question 10 of 19

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