Multisystem: Shock, Sepsis and Metabolic Syndromes · USMLE Step 1

A patient presents with confusion after fasting for 24 hours. Serum glucose is 45 mg/dL. Which hormone is MOST responsible for initial counter-regulation?

  1. Insulin
  2. Glucagon
  3. Epinephrine
  4. Cortisol
Show answer and explanation

Correct answer: Glucagon

Glucagon is the first hormone to increase during hypoglycemia, stimulating hepatic glucose release. Epinephrine and cortisol act later.

Difficulty: Medium Question 12 of 19

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