Multisystem: Shock, Sepsis and Metabolic Syndromes · USMLE Step 1

A 56-year-old man presents with hypotension, warm flushed skin, and bounding pulses. He is febrile and confused. Which mechanism best explains his shock state?

  1. Reduced cardiac output from myocardial depression
  2. Widespread vasodilation due to nitric oxide release
  3. Severe intravascular volume loss from hemorrhage
  4. Mechanical obstruction of venous return
Show answer and explanation

Correct answer: Widespread vasodilation due to nitric oxide release

Septic shock causes massive vasodilation via cytokine-mediated nitric oxide release. This results in warm skin, hypotension, and distributive shock.

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