Gastrointestinal: Liver Disease, IBD · USMLE Step 1

A newborn develops jaundice within 24 hours of birth and has high unconjugated bilirubin. Which condition is most likely?

  1. Biliary atresia
  2. Crigler–Najjar syndrome
  3. Dubin–Johnson syndrome
  4. Rotor syndrome
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Correct answer: Crigler–Najjar syndrome

Crigler–Najjar syndrome type I causes severe unconjugated hyperbilirubinemia due to absent UDP-glucuronyl transferase.

Difficulty: Medium Question 20 of 20

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