Viruses: Life Cycle and Disease · USMLE Step 1

A man develops severe watery diarrhea after a cruise. Stool PCR detects Norovirus. What is the genome of this virus?

  1. Enveloped double-stranded DNA
  2. Non-enveloped positive-sense RNA
  3. Enveloped negative-sense RNA
  4. Segmented double-stranded RNA
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Correct answer: Non-enveloped positive-sense RNA

Norovirus is a non-enveloped, positive-sense RNA virus commonly associated with outbreaks on cruise ships.

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