Vaccines and Immunoprophylaxis · USMLE Step 1

A healthcare worker is exposed to hepatitis B but has never been vaccinated. What is the recommended post-exposure prophylaxis?

  1. Hepatitis B vaccine only
  2. Hepatitis B immunoglobulin only
  3. HBIG plus hepatitis B vaccine
  4. No prophylaxis needed
Show answer and explanation

Correct answer: HBIG plus hepatitis B vaccine

Unvaccinated individuals require both passive (HBIG) and active (vaccine) immunization. This prevents acute infection.

Difficulty: Medium Question 12 of 20

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