Vaccines and Immunoprophylaxis · USMLE Step 1

Which type of vaccine is most effective at producing mucosal IgA immunity?

  1. Inactivated vaccine
  2. Live attenuated vaccine
  3. Subunit vaccine
  4. Toxoid vaccine
Show answer and explanation

Correct answer: Live attenuated vaccine

Live attenuated vaccines stimulate replication at mucosal sites, generating strong IgA responses. This improves protection against mucosal pathogens.

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