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Microbiology and Immunology

Vaccines and Immunoprophylaxis Practice Questions

20 free Vaccines and Immunoprophylaxis practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.

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All Vaccines and Immunoprophylaxis questions

20 questions
  1. Q1. A 2-month-old infant receives the DTaP vaccine. Which type of vaccine protects against tetanus?
  2. Q2. A patient traveling to an area with yellow fever receives the yellow fever vaccine. Which type of vaccine is this?
  3. Q3. A 6-month-old infant receives the Haemophilus influenzae type b (Hib) vaccine. What type of vaccine is this?
  4. Q4. A traveler is exposed to rabies and receives rabies immunoglobulin plus the rabies vaccine. What type of immunity do these provide?
  5. Q5. A patient with chronic lung disease receives the annual influenza vaccine. Which formulation is recommended for adults?
  6. Q6. A child with SCID should NOT receive which vaccine?
  7. Q7. Which vaccine is recommended to prevent shingles in older adults?
  8. Q8. A pregnant woman should receive which vaccine during each pregnancy?
  9. Q9. Which vaccine prevents infection by a virus with circular, partially double-stranded DNA?
  10. Q10. A child receives the rotavirus vaccine. Which type of vaccine is it?
  11. Q11. Which vaccine is required for functional asplenic patients due to increased susceptibility to encapsulated bacteria?
  12. Q12. A healthcare worker is exposed to hepatitis B but has never been vaccinated. What is the recommended post-exposure prophylaxis?
  13. Q13. Which vaccine is contraindicated in infants younger than 6 weeks?
  14. Q14. A patient receives a vaccine containing purified polysaccharide antigens that stimulate B cells without T-cell help. Which vaccine fits this description?
  15. Q15. Which vaccine uses recombinant subunit technology to prevent cervical cancer?
  16. Q16. Which type of vaccine is most effective at producing mucosal IgA immunity?
  17. Q17. A child receives an oral polio vaccine in a country where it is still used. What advantage does OPV have over IPV?
  18. Q18. Which vaccine is associated with rare immune-mediated thrombocytopenia and Guillain–Barré syndrome?
  19. Q19. A newborn receives intramuscular vitamin K. What type of prevention does this represent?
  20. Q20. Which pathogen requires both pre-exposure and post-exposure prophylaxis in high-risk laboratory workers?