Bacteria: Structure and Pathogenesis · USMLE Step 1

Which structural difference allows some Gram-negative bacteria to resist certain antibiotics and harsh chemicals better than Gram-positive bacteria?

  1. Exceptionally thick peptidoglycan layer
  2. Outer membrane with LPS and porins
  3. High surface teichoic acid content
  4. Complete absence of any capsule
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Correct answer: Outer membrane with LPS and porins

The outer membrane of Gram-negative bacteria, with LPS and porins, serves as an effective barrier against many antibiotics and toxic substances.

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