Histopathology basics · USMLE Step 1

Which of the following best defines Hyperplasia in histopathology?

Abnormal, disorganized cell growth that forms a tumor mass
Increase in cell size without any increase in cell number
Increased cell number enlarging the tissue in response to a stimulus
Replacement of one mature cell type by another type

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Correct answer: Increased cell number enlarging the tissue in response to a stimulus

Hyperplasia refers to an increase in the number of cells in a tissue, often as a predictable response to a stimulus (e.g., hormonal), resulting in tissue enlargement while maintaining normal organization.

Difficulty: Medium Question 18 of 22

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