Embryologic Development and Defects · USMLE Step 1

A fetus shows intestinal contents within the umbilical cord covered by peritoneum. This condition is caused by which embryologic failure?

  1. Failure of the lateral folds to fuse
  2. Persistent physiologic midgut herniation
  3. Failure of recanalization of the duodenum
  4. Persistence of the urachus
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Correct answer: Persistent physiologic midgut herniation

Omphalocele occurs when physiologic herniation of the midgut fails to return to the abdominal cavity. The herniated organs remain covered by peritoneum.

Difficulty: Medium Question 18 of 20

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