Embryologic Development and Defects · USMLE Step 1

A newborn presents with Potter sequence. Which embryologic abnormality most likely caused this condition?

  1. Failure of ureteric bud to develop
  2. Incomplete recanalization of urethra
  3. Persistent cloacal membrane
  4. Failure of the Mullerian ducts to fuse
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Correct answer: Failure of ureteric bud to develop

Bilateral renal agenesis results from failure of the ureteric bud to develop and induces oligohydramnios. This causes the characteristic features of Potter sequence.

Difficulty: Medium Question 17 of 20

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